Reclamation

This exhibition will take the form of a group show of African artists who weave cultural heritage with the contemporary, to challenge Western perceptions of African art and culture. Artists Wole Langunju (Nigeria), Prudence Chimutuwah (Zimbabwe), Lincoln Mwangi (Kenya), Moira Bushkimani (Kenya), and Angèle Etoundi Essamba (Cameroon) are confirmed to participate. In addition to the contemporary works by these artists on display, two Nigerian Gèlèdé masks have been generously loaned from the private collection of Olusanya Ojikutu, one from the early 20th century and, the other, whose dating is undetermined. In showcasing these works in tandem, the exhibition creates a connection both tangible and visual between the works of the past and their evolution to the present day

Towards the prediction of critical transitions in spatially extended populations with cubical homology

The prediction of critical transitions, such as extinction events, is vitally important to preserving vulnerable populations in the face of a rapidly changing climate and continuously increasing human resource usage. Predicting such events in spatially distributed populations is challenging because of the high dimensionality of the system and the complexity of the system dynamics. Here, we reduce the dimensionality of the problem by quantifying spatial patterns via Betti numbers ($\beta_0$ and $\beta_1$), which count particular topological features in a topological space. Spatial patterns representing regions occupied by the population are analyzed in a coupled patch population model with Ricker map growth and nearest-neighbors dispersal on a two-dimensional lattice. We illustrate how Betti numbers can be used to characterize spatial patterns by type, which in turn may be used to track spatiotemporal changes via Betti number time series and characterize asymptotic dynamics of the model parameter space. En route to a global extinction event, we find that the Betti number time series of a population exhibits characteristic changes. We hope these preliminary results will be used to aide in the prediction of critical transitions in spatially extended systems. Additional applications of this technique include analysis of spatial data (e.g., GIS) and model validation.Comment: Published in Contemporary Mathematics: Dynamical Systems and Random Processes, Volume 736, 201

Rare variants contribute disproportionately to quantitative trait variation in yeast.

How variants with different frequencies contribute to trait variation is a central question in genetics. We use a unique model system to disentangle the contributions of common and rare variants to quantitative traits. We generated ~14,000 progeny from crosses among 16 diverse yeast strains and identified thousands of quantitative trait loci (QTLs) for 38 traits. We combined our results with sequencing data for 1011 yeast isolates to show that rare variants make a disproportionate contribution to trait variation. Evolutionary analyses revealed that this contribution is driven by rare variants that arose recently, and that negative selection has shaped the relationship between variant frequency and effect size. We leveraged the structure of the crosses to resolve hundreds of QTLs to single genes. These results refine our understanding of trait variation at the population level and suggest that studies of rare variants are a fertile ground for discovery of genetic effects

Physical activity is prospectively associated with adolescent nonalcoholic fatty liver disease

Objectives: The aim of the present study was to assess whether objectively measured physical activity at mean ages 12 and 14 years are prospectively associated with ultrasound scan liver fat and stiffness (alanine aminotransferase, aspartate aminotransferase [AST], and [gamma]-glutamyl transferase [GGT]) assessed at mean age 17.8 years. Methods: Participants were from the Avon Longitudinal Study of Parents and Children. Total physical activity (counts per minute) and minutes of moderate to vigorous physical activity (MVPA) were measured using ActiGraph accelerometers at mean ages 12 and 14 years. Results: Greater total physical activity and MVPA at ages 12 and 14 years were associated with lower odds of liver fat and lower GGT levels at mean age 17.8 years, such as per 15-minute increase in daily MVPA at age 12 years, the confounder adjusted odds ratio of liver fat was 0.47 (95% confidence interval [CI] 0.27–0.84). Associations attenuated after additional adjustment for fat mass as a potential confounder (eg, per 15-minute increase in daily MVPA at age 12 years, the odds ratio of liver fat attenuated to 0.65 [95% CI 0.35–1.21]) or a potential mediator (eg, per 15-minute increase in daily MVPA at age 12 years the odds ratio of liver fat attenuated to 0.59 [95% CI 0.32–1.09]). Results did not further attenuate after additional adjustment for insulin resistance. There was some evidence that greater total physical activity and MVPA at age 12 years were associated with the higher AST levels. Conclusions: Adolescents who were more active in childhood have lower odds of fatty liver and lower GGT levels. These findings are likely to be, at least in part, explained by adiposity

Weight trajectories through infancy and childhood and risk of non-alcoholic fatty liver disease in adolescence: the ALSPAC study

Background and Aims: Adiposity is a key risk factor for NAFLD. Few studies have examined prospective associations of infant and childhood adiposity with subsequent NAFLD risk. We examined associations of weight-for-height trajectories from birth to age 10 with liver outcomes in adolescence, and assessed the extent to which associations are mediated through fat mass at the time of outcome assessment.<p></p> Methods: Individual trajectories of weight and height were estimated for participants in the Avon Longitudinal Study of Parents and Children using random-effects linear-spline models. Associations of birthweight (adjusted for birth length) and weight change (adjusted for length/height change) from 0–3 months, 3 months–1 y, 1–3 y, 3–7 y, and 7–10 y with ultrasound scan (USS) determined liver fat and stiffness, and serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT) at mean age 17.8 y were assessed with linear and logistic regressions. Mediation by concurrent fat mass was assessed with adjustment for fat mass at mean age 17.8 y.<p></p> Results: Birth weight was positively associated with liver stiffness and negatively with ALT and AST. Weight change from birth to 1 y was not associated with outcomes. Weight change from 1–3 y, 3–7 y, and 7–10 y was consistently positively associated with USS and blood-based liver outcomes. Adjusting for fat mass at mean age 17.8 y attenuated associations toward the null, suggesting associations are largely mediated by concurrent body fatness.<p></p> Conclusions: Greater rates of weight-for-height change between 1 y and 10 y are consistently associated with adverse liver outcomes in adolescence. These associations are largely mediated through concurrent fatness

Environmental enrichment provided to adult Zebra Finches (Taeniopygia guttata) differentially influences sexes on a spatial learning task

Presenter: Arma\u27Rosa Wilks-Moheadhttps://egrove.olemiss.edu/pharm_annual_posters_2021/1000/thumbnail.jp